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Journal: American Journal of Translational Research
Article Title: Repair phase modeling of ischemic acute kidney injury: recovery vs. transition to chronic kidney disease
doi:
Figure Lengend Snippet: Expressions of intrarenal cytokines/chemokines and TGF-β1 following IRI. A. The expression of MCP-1, RANTES, TNF-α, and IL-6 were significantly higher in the UIRI group than those in the control and BIRI groups. The expression of VEGF was lower in the UIRI group than that in the control and BIRI groups. *P<0.05 (n=5-8 in each group). Statistical analyses were performed using ANOVA followed by Tukey’s post-hoc analysis. B. The expression of TGF-β1 was significantly higher in the UIRI group than in the control and BIRI groups (n=5-10 in each group). Statistical analyses were performed using ANOVA followed by Tukey’s post-hoc analysis. BIRI, bilateral ischemia-reperfusion injury; IRI, ischemia-reperfusion injury; MCP-1, monocyte chemoattractant protein-1; RANTES, regulated on activation, normal T cell expressed and secreted (CCL5); UIRI, unilateral ischemia-reperfusion injury; TGF-β1, transforming growth factor-β1.
Article Snippet: The intrarenal transforming growth factor (TGF)-β1 expression was measured using a
Techniques: Expressing, Activation Assay